BODIO Ewen Voir la fiche profil en français

Since 2019  Full Professor ICMUB
(Institut de Chimie Moléculaire de l’Université de Bourgogne UMR CNRS 6302)
P.I. of metal-based theranostics axis and co-P.I. of aza-BODIPYs axis
Main project: Design of theranostics, bimodal probes, near-infrared optical probes for applications in in vitro and in vivo medicine.
Main fields of expertise: organic chemistry, coordination chemistry, bioinorganic, medical imaging (optical, PET, SPECT), catalysis  

2010-2019  Assistant Professor ICMUB
Group P.I.: Prof. Pierre Le Gendre
Organic and organometallic synthesis applied to medical imaging, therapy, and catalysis

2009-2010  Postdoctoral position (ERC grant) School of Chemistry, Trinity College 
University of Dublin, Ireland
Supervisor: Prof. Stephen Connon
Organocatalysis, amines kinectic resolution, and design of artificial enzyme

2006-2009  PhD (CNRS grant) CEISAM Lab
(Chimie Et Interdisciplinéarité: Synthèse, Analyse, Modélisation), UMR CNRS 6230 of Université de Nantes, France
Supervisor: Prof. David Deniaud – Co-supervisor: Dr Karine Julienne
Synthesis of « N₂S₂ » / « N₄ » chelating agents for nuclear medicine applications

2005-2006  Master in Biomolecular Engineering - Montpellier (UMII), France

2003-2006  « Ingénieur en Chimie » - ENSIACET, Toulouse, France
Specialization in advanced organic chemistry at ENSCM, Montpellier, France

Projects as Principal Investigator (or co-P.I.)

- Lipid derivatives against obesity 2023 (financement EktaH® ≈ 30 k€ + demande de CIFRE)
- FluoNIR-II 2022 (maturation contract for start-up creation – 260 k€)
- ANR PRC 2021 “MAP” (Metal azaDIPY probe – 520 k€)
- ANER 2020 “AZTHEC” (Metal-based aza-BODIPY – 129 k€)
- ANR JCJC 2016 “SPID” (Smart Probe for Imaging metal-based Drugs – 230 k€)
- PARI II – 3-p2 (metal-based theranostics – 75 k€)
- BQR PRESS (biosourced theranostics – 15 k€)
- projet INFIniTI – CNRS SIIM (theoretical study of smart probes – 3 k€)
- 3 JCE/ICE PhD program (young researcher-entrepreneur – 3x 99 k€)
- PARI p5 subproject of 3MIM program (Trackable metal-based therapeutics – 180 k€)
- “bioinorganic and medicinal chemistry” theme of the ICMUB - “Health axis” of OCS Team

+ Several other projects as WP leader or participant

Last Publications 

Tailored hyaluronic acid-based nanogels as theranostic boron delivery systems for boron neutron cancer therapy
Coninx, S., Kalot, G., Godard, A., Bodio, E., Goze, C., Sancey, L., Auzely-Velty, R.*
Int. J. Pharm.: X, 2022, 4, 100134
https://doi.org/10.1016/j.ijpx.2022.100134

Phenoxy-Amidine Ligands: Toward Lactic Acid-Tolerant Catalysts for Lactide Ring-Opening Polymerization
Vaillant-Coindard, V., Theron, B., Printz, G., Chotard, F., Balan, C., Rousselin, Y., Richard, P., Tolbatov, I., Fleurat-Lessard, P., Bodio, E., Malacea-Kabbara, R.,* Bayardon, J., Dagorne, S.,* Le Gendre, P.*
Organometallics, 2022, 41(21), 2920-2932
https://doi.org/10.1021/acs.organomet.2c00343

Al(III) and Ga(III) Bisphenolate Azadipyrromethene-Based "N₂O₂" Complexes as Efficient NIR-Fluorophores
Godard, A., Galan, L. A., Rouillon, J., Al Shehimy, S., Tajani, W., Cave, C., Malacea-Kabbara, R., Rousselin, Y., Le Gendre, P., Fihey, A., Bendellaa, M., Busser, B., Sancey, L., Le Guennic, B., Bucher, C., Maury, O., Goze, C., Bodio, E.*
Inorg. Chem., 2022, asap
https://doi.org/10.1021/acs.inorgchem.2c03918

Couverture Synthesis, in vivo Investigations, Conception and Evaluation of Fluorescent Phosphine-Gold Complexes
Rousselle, B., Massot, A., Privat, M., Dondaine, L., Trommenschlager, A., Bouyer, F., Bayardon, J., Ghiringhelli, F., Bettaieb, A., Goze, C., Paul, C., Malacea-Kabbara, R.,* Bodio, E.*
ChemMedChem, 2022, 17(11), e202100773
https://doi.org/10.1002/cmdc.202100773
Cover

Lipoprotein interactions with water-soluble NIR-II emitting aza-BODIPYs boost the fluorescence signal and favor selective tumor targeting
Kalot, G., Godard, A., Busser, B., Bendellaa, M., Dalonneau, F., Paul, C., Le Guevel, X., Josserand, V., Coll, J.-L., Denat, F., Bodio, E., Goze, C., Gautier, T., Sancey, L.*
Biomaterials Science, 2022, 10(21), 6315-6325
https://doi.org/10.1039/D2BM01271E

Recent patents

Sancey, L., Goze, C., Bodio, E., Busser, B., Pliquett, J., Godard, A., Kalot, G., Josserand, V., Le Guével, X., Coll, J.L., Denat, F.
Université Grenoble Alpes, CNRS, INSERM, Univ. de Bourgogne
Eur. Pat. Appl. (2021), EP 3772528 A1 20210210
PCT Int. Appl. (2021), WO 2021023731 A1 20210211
US Patent App. (2022), 17/633,610, 2022

Teaching
2010 - ... > 230 h/year (CM/TD/TP – L3/M1/M2) / 2022-2023 (≈ 260 h)
- organic chemistry (retrosynthesis, total synthesis...) [bachelor/Master]
- Spectroscopic methods [Bachelor/Master]
- Molecular imaging [Master]
- Theranostics [Master]
- Environnemental analyses [Master]
- Project management [Master]

Teaching Responsabilities
2019 - ... Head of international Molecular Chemistry Master
2019 - ... M1 Innovative Drugs pedagogical advisor (molecular chemistry)
2017 - ... Co-leader of double degree with UCT Prague
2016 - ... Head of T2MC Master Specialty (Transition Metal in Molecular Chemistry)
2013 - ... Creation of an international master in imaging (Master LipTherapy)

Project management
P.I. of the I-site Master international Molecular Chemistry project
P.I. of PIA 3 - RITM-BFC project on pedagogical innovation
Co-leader of the project I-SITE “strengthened bachelor”
WP leader of the Graduate school UBFC Integrate
WP leader of the I-site Master international Innovative Drugs project

Administratives Responsabilities

2022 - ...   Member of “bureau de la commission de proposition section 31-32-33 de l’uB”
2020 - 21  Member of CNRS National committee « chemistry for life sciences » - section 16
2017 - ...   Communication manager of ICMUB
2014 - ...   IT advisor of the ICMUB
2012 - 19  Committee Member of Scientific council of ICMUB